2ai9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ai9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ai9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ai9| PDB=2ai9 | SCENE= }}
{{STRUCTURE_2ai9| PDB=2ai9 | SCENE= }}
-
'''S.aureus Polypeptide Deformylase'''
+
===S.aureus Polypeptide Deformylase===
-
==Overview==
+
<!--
-
Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report the crystal structures of polypeptide deformylase from four different species of bacteria: Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Comparison of these four structures reveals significant overall differences between the two Gram-negative species (E. coli and H. influenzae) and the two Gram-positive species (S. pneumoniae and S. aureus). Despite these differences and low overall sequence identity, the S1' pocket of PDF is well conserved among the four enzymes studied. We also describe the binding of nonpeptidic inhibitor molecules SB-485345, SB-543668, and SB-505684 to both S. pneumoniae and E. coli PDF. Comparison of these structures shows similar binding interactions with both Gram-negative and Gram-positive species. Understanding the similarities and subtle differences in active site structure between species will help to design broad-spectrum polypeptide deformylase inhibitor molecules.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12538898}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12538898 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12538898}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Smyth, M.]]
[[Category: Smyth, M.]]
[[Category: Hudrolase]]
[[Category: Hudrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:05:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:39:27 2008''

Revision as of 09:39, 28 July 2008

Image:2ai9.png

Template:STRUCTURE 2ai9

S.aureus Polypeptide Deformylase

Template:ABSTRACT PUBMED 12538898

About this Structure

2AI9 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species., Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB, Protein Sci. 2003 Feb;12(2):349-60. PMID:12538898

Page seeded by OCA on Mon Jul 28 12:39:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ai9"
Personal tools