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2duv
From Proteopedia
(New page: 200px<br /> <applet load="2duv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2duv, resolution 2.2Å" /> '''Structure of CDK2 wi...) |
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| - | [[Image:2duv. | + | [[Image:2duv.jpg|left|200px]]<br /><applet load="2duv" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2duv" size=" | + | |
caption="2duv, resolution 2.2Å" /> | caption="2duv, resolution 2.2Å" /> | ||
'''Structure of CDK2 with a 3-hydroxychromones'''<br /> | '''Structure of CDK2 with a 3-hydroxychromones'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2DUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 371 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Full crystallographic information is available from [http:// | + | 2DUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=371:'>371</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: serine/threonine-protein kinase]] | [[Category: serine/threonine-protein kinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:22:36 2008'' |
Revision as of 15:22, 15 February 2008
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Structure of CDK2 with a 3-hydroxychromones
Overview
A novel series of 3-hydroxychromones were prepared and found to be CDK, inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and, CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
About this Structure
2DUV is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Cyclin-dependent kinase, with EC number 2.7.11.22 Full crystallographic information is available from OCA.
Reference
3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224
Page seeded by OCA on Fri Feb 15 17:22:36 2008
