2an2

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[[Image:2an2.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2an2| PDB=2an2 | SCENE= }}
{{STRUCTURE_2an2| PDB=2an2 | SCENE= }}
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'''P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase'''
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===P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase===
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==Overview==
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Cooperativity among ligand binding, subunit association, and protein folding has implications for enzyme regulation as well as protein aggregation events associated with disease. The binding of substrate l-arginine or cofactor tetrahydrobiopterin converts nitric oxide synthases (NOSs) from a "loose dimer", with an exposed active center and higher sensitivity to proteolysis, to a "tight dimer" competent for catalysis. The crystallographic structure of the Bacillus subtilis NOS loose dimer shows an altered association state with severely destabilized subdomains. Ligand binding or heme reduction converts loose dimers to tight dimers in solution and crystals. Mutations at key positions in the dimer interface that distinguish prokaryotic from eukaryotic NOSs affect the propensity to form loose dimers. The loose dimer structure indicates that non-native interactions can mediate subunit association in NOS.
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(as it appears on PubMed at http://www.pubmed.gov), where 16126221 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16126221}}
==About this Structure==
==About this Structure==
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[[Category: Pant, K.]]
[[Category: Pant, K.]]
[[Category: Double mutant]]
[[Category: Double mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:14:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:36:18 2008''

Revision as of 00:36, 28 July 2008

Image:2an2.png

Template:STRUCTURE 2an2

P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase

Template:ABSTRACT PUBMED 16126221

About this Structure

2AN2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of a loose dimer: an intermediate in nitric oxide synthase assembly., Pant K, Crane BR, J Mol Biol. 2005 Sep 30;352(4):932-40. PMID:16126221

Page seeded by OCA on Mon Jul 28 03:36:18 2008

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