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2ana

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{{STRUCTURE_2ana| PDB=2ana | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF D(G-G-G-G-C-C-C-C). A MODEL FOR POLY(DG).POLY(DC)'''
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===THE CRYSTAL STRUCTURE OF D(G-G-G-G-C-C-C-C). A MODEL FOR POLY(DG).POLY(DC)===
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==Overview==
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The structure of the DNA oligomer d(G-G-G-G-C-C-C-C) has been determined at a resolution of 2.5 A by single-crystal X-ray methods. There are two strands in the asymmetric unit, and these coil about each other to form a right-handed double-helix of the A-type with Watson-Crick hydrogen bonds between base-pairs. The helix has a shallow minor groove and a deep, water-filled major groove; almost all exposed functional groups on the DNA are hydrated, and 106 ordered solvent molecules have been found. The two d(G-G-G-G).d(C-C-C-C) segments in the octamer exhibit similar and uniform structures, but there is a slight discontinuity at the GpC step between them. A recurring feature of the structure is the overlap of adjacent guanine bases in each GpG step, with the five-membered ring of one guanine stacking on the six-membered ring of its neighbour. There is little or no overlap between adjacent cytosine rings. Conformational parameters for these GpG steps are compared with those from other single-crystal X-ray analyses. In general, GpG steps exhibit high slide, low roll and variable twist. Models for poly(dG).poly(dC) were generated by applying a simple rotation and translation to each of the unmodified d(G-G-G-G).d(C-C-C-C) units. Detailed features of these models are shown to be compatible with various assays of poly(dG).poly(dC) in solution, and are useful in understanding the polymorphic behaviour of this sequence under a variety of experimental conditions.
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(as it appears on PubMed at http://www.pubmed.gov), where 4020865 is the PubMed ID number.
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{{ABSTRACT_PUBMED_4020865}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
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[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:23:24 2008''

Revision as of 09:23, 28 July 2008

Image:2ana.png

Template:STRUCTURE 2ana

THE CRYSTAL STRUCTURE OF D(G-G-G-G-C-C-C-C). A MODEL FOR POLY(DG).POLY(DC)

Template:ABSTRACT PUBMED 4020865

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of d(G-G-G-G-C-C-C-C). A model for poly(dG).poly(dC)., McCall M, Brown T, Kennard O, J Mol Biol. 1985 Jun 5;183(3):385-96. PMID:4020865

Page seeded by OCA on Mon Jul 28 12:23:24 2008

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