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2ane

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{{STRUCTURE_2ane| PDB=2ane | SCENE= }}
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'''Crystal structure of N-terminal domain of E.Coli Lon Protease'''
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===Crystal structure of N-terminal domain of E.Coli Lon Protease===
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==Overview==
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We report here the first crystal structure of the N-terminal domain of an A-type Lon protease. Lon proteases are ubiquitous, multidomain, ATP-dependent enzymes with both highly specific and non-specific protein binding, unfolding, and degrading activities. We expressed and purified a stable, monomeric 119-amino acid N-terminal subdomain of the Escherichia coli A-type Lon protease and determined its crystal structure at 2.03 A (Protein Data Bank [PDB] code 2ANE). The structure was solved in two crystal forms, yielding 14 independent views. The domain exhibits a unique fold consisting primarily of three twisted beta-sheets and a single long alpha-helix. Analysis of recent PDB depositions identified a similar fold in BPP1347 (PDB code 1ZBO), a 203-amino acid protein of unknown function from Bordetella parapertussis, crystallized as part of a structural genomics effort. BPP1347 shares sequence homology with Lon N-domains and with a family of other independently expressed proteins of unknown functions. We postulate that, as is the case in Lon proteases, this structural domain represents a general protein and polypeptide interaction domain.
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{{ABSTRACT_PUBMED_16199667}}
==About this Structure==
==About this Structure==
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[[Category: Lon protease]]
[[Category: Lon protease]]
[[Category: Lonn119]]
[[Category: Lonn119]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:11:53 2008''

Revision as of 08:12, 28 July 2008

Image:2ane.png

Template:STRUCTURE 2ane

Crystal structure of N-terminal domain of E.Coli Lon Protease

Template:ABSTRACT PUBMED 16199667

About this Structure

2ANE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal domain of E. coli Lon protease., Li M, Rasulova F, Melnikov EE, Rotanova TV, Gustchina A, Maurizi MR, Wlodawer A, Protein Sci. 2005 Nov;14(11):2895-900. Epub 2005 Sep 30. PMID:16199667

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