2apq

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[[Image:2apq.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2apq| PDB=2apq | SCENE= }}
{{STRUCTURE_2apq| PDB=2apq | SCENE= }}
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'''Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.'''
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===Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.===
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==Overview==
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Amyloid or amyloid-like fibrils are elongated, insoluble protein aggregates, formed in vivo in association with neurodegenerative diseases or in vitro from soluble native proteins, respectively. The underlying structure of the fibrillar or 'cross-beta' state has presented long-standing, fundamental puzzles of protein structure. These include whether fibril-forming proteins have two structurally distinct stable states, native and fibrillar, and whether all or only part of the native protein refolds as it converts to the fibrillar state. Here we show that a designed amyloid-like fibril of the well-characterized enzyme RNase A contains native-like molecules capable of enzymatic activity. In addition, these functional molecular units are formed from a core RNase A domain and a swapped complementary domain. These findings are consistent with the zipper-spine model in which a cross-beta spine is decorated with three-dimensional domain-swapped functional units, retaining native-like structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_16148936}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16148936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16148936}}
==About this Structure==
==About this Structure==
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[[Category: Sambashivan, S.]]
[[Category: Sambashivan, S.]]
[[Category: Sawaya, M R.]]
[[Category: Sawaya, M R.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:55:04 2008''

Revision as of 17:55, 28 July 2008

Image:2apq.png

Template:STRUCTURE 2apq

Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.

Template:ABSTRACT PUBMED 16148936

About this Structure

2APQ is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure., Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D, Nature. 2005 Sep 8;437(7056):266-9. PMID:16148936

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