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2aqc

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[[Image:2aqc.gif|left|200px]]
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{{STRUCTURE_2aqc| PDB=2aqc | SCENE= }}
{{STRUCTURE_2aqc| PDB=2aqc | SCENE= }}
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'''NMR Structural analysis of archaeal Nop10'''
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===NMR Structural analysis of archaeal Nop10===
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==Overview==
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Box H/ACA ribonucleoprotein particles (RNPs) catalyze RNA pseudouridylation and direct processing of ribosomal RNA, and are essential architectural components of vertebrate telomerases. H/ACA RNPs comprise four proteins and a multihelical RNA. Two proteins, Cbf5 and Nop10, suffice for basal enzymatic activity in an archaeal in vitro system. We now report their cocrystal structure at 1.95-A resolution. We find that archaeal Cbf5 can assemble with yeast Nop10 and with human telomerase RNA, consistent with the high sequence identity of the RNP components between archaea and eukarya. Thus, the Cbf5-Nop10 architecture is phylogenetically conserved. The structure shows how Nop10 buttresses the active site of Cbf5, and it reveals two basic troughs that bidirectionally extend the active site cleft. Mutagenesis results implicate an adjacent basic patch in RNA binding. This tripartite RNA-binding surface may function as a molecular bracket that organizes the multihelical H/ACA and telomerase RNAs.
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{{ABSTRACT_PUBMED_16286935}}
==About this Structure==
==About this Structure==
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2AQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQC OCA].
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2AQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQC OCA].
==Reference==
==Reference==
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[[Category: Anop10]]
[[Category: Anop10]]
[[Category: Zinc-ribbon]]
[[Category: Zinc-ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:20:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:29:52 2008''

Revision as of 20:29, 28 July 2008

Image:2aqc.png

Template:STRUCTURE 2aqc

NMR Structural analysis of archaeal Nop10

Template:ABSTRACT PUBMED 16286935

About this Structure

2AQC is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full experimental information is available from OCA.

Reference

The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs., Hamma T, Reichow SL, Varani G, Ferre-D'Amare AR, Nat Struct Mol Biol. 2005 Dec;12(12):1101-7. Epub 2005 Nov 15. PMID:16286935

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