2arv

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[[Image:2arv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2arv| PDB=2arv | SCENE= }}
{{STRUCTURE_2arv| PDB=2arv | SCENE= }}
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'''Structure of human Activin A'''
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===Structure of human Activin A===
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==Overview==
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The secreted, multidomain protein follistatin binds activins with high affinity, inhibiting their receptor interaction. We have dissected follistatin's domain structure and shown that the minimal activin-inhibiting fragment of follistatin is comprised of the first and second Fs domains (Fs12). This protein can bind to activin dimer and form a stable complex containing two Fs12 molecules and one activin dimer. We have solved crystal structures of activin A alone and its complex with Fs12 fragment to 2 A resolution. The complex structure shows how Fs12 molecules wrap around the back of the 'wings' of activin, blocking the type II receptor-binding site on activin A. Arginine 192 in Fs2 is a key residue in this interaction, inserting itself in between activin's fingers. Complex formation imposes a novel orientation for the EGF- and Kazal-like subdomains in the Fs2 domain and activin A shows further variation from the canonical TGF-beta family fold. The structure provides a detailed description of the inhibitory mechanism and gives insights into interactions of follistatin with other TGF-beta family proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_16482217}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16482217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16482217}}
==About this Structure==
==About this Structure==
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[[Category: Disulfide linked]]
[[Category: Disulfide linked]]
[[Category: Homodimer,cystine knot]]
[[Category: Homodimer,cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:24:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:25:47 2008''

Revision as of 01:25, 28 July 2008

Image:2arv.png

Template:STRUCTURE 2arv

Structure of human Activin A

Template:ABSTRACT PUBMED 16482217

About this Structure

2ARV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of activin signalling by follistatin., Harrington AE, Morris-Triggs SA, Ruotolo BT, Robinson CV, Ohnuma S, Hyvonen M, EMBO J. 2006 Mar 8;25(5):1035-45. Epub 2006 Feb 16. PMID:16482217

Page seeded by OCA on Mon Jul 28 04:25:47 2008

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