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2asq

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[[Image:2asq.gif|left|200px]]
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{{STRUCTURE_2asq| PDB=2asq | SCENE= }}
{{STRUCTURE_2asq| PDB=2asq | SCENE= }}
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'''Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM)'''
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===Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM)===
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==Overview==
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Sumoylation has recently been identified as an important mechanism that regulates protein interactions and localization in essential cellular functions, such as gene transcription, subnuclear structure formation, viral infection, and cell cycle progression. A SUMO binding amino acid sequence motif (SBM), which recognizes the SUMO moiety of modified proteins in sumoylation-dependent cellular functions, has been consistently identified by several recent studies. To understand the mechanism of SUMO recognition by the SBM, we have solved the solution structure of SUMO-1 in complex with a peptide containing the SBM derived from the protein PIASX (KVDVIDLTIESSSDEEEDPPAKR). Surprisingly, the structure reveals that the bound orientation of the SBM can reverse depending on the sequence context. The structure also reveals a novel mechanism of recognizing target sequences by a ubiquitin-like module. Unlike ubiquitin binding motifs, which all form helices and bind to the main beta-sheet of ubiquitin, the SBM forms an extended structure that binds between the alpha-helix and a beta-strand of SUMO-1. This study provides a clear mechanism of the SBM sequence variations and its recognition of the SUMO moiety in sumoylated proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_16204249}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16204249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16204249}}
==About this Structure==
==About this Structure==
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2ASQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASQ OCA].
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2ASQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASQ OCA].
==Reference==
==Reference==
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[[Category: Sumo-1]]
[[Category: Sumo-1]]
[[Category: Sumo-binding motif]]
[[Category: Sumo-binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:26:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:45:26 2008''

Revision as of 05:45, 29 July 2008

Image:2asq.png

Template:STRUCTURE 2asq

Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM)

Template:ABSTRACT PUBMED 16204249

About this Structure

2ASQ is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation., Song J, Zhang Z, Hu W, Chen Y, J Biol Chem. 2005 Dec 2;280(48):40122-9. Epub 2005 Oct 3. PMID:16204249

Page seeded by OCA on Tue Jul 29 08:45:26 2008

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