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2auk

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[[Image:2auk.gif|left|200px]]
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{{STRUCTURE_2auk| PDB=2auk | SCENE= }}
{{STRUCTURE_2auk| PDB=2auk | SCENE= }}
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'''Structure of E. coli RNA polymerase beta' G/G' insert'''
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===Structure of E. coli RNA polymerase beta' G/G' insert===
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==Overview==
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The large beta and beta' subunits of the bacterial core RNA polymerase (RNAP) are highly conserved throughout evolution. Nevertheless, large sequence insertions in beta and beta' characterize specific evolutionary lineages of bacteria. The Thermus aquaticus RNAP beta' subunit contains a 283 residue insert between conserved regions A and B that is found in only four bacterial species. The Escherichia coli RNAP beta' subunit contains a 188 residue insert in the middle of conserved region G that is found in a wide range of bacterial species. Here, we present structural studies of these two beta' insertions. We show that the inserts comprise repeats of a previously characterized fold, the sandwich-barrel hybrid motif (as predicted from previous sequence analysis) and that the inserts serve significant roles in facilitating protein/protein and/or protein/nucleic acid interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 16154587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16154587}}
==About this Structure==
==About this Structure==
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[[Category: Nikiforov, V.]]
[[Category: Nikiforov, V.]]
[[Category: Sandwich-barrel hybrid motif]]
[[Category: Sandwich-barrel hybrid motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:29:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:59 2008''

Revision as of 03:00, 29 July 2008

Image:2auk.png

Template:STRUCTURE 2auk

Structure of E. coli RNA polymerase beta' G/G' insert

Template:ABSTRACT PUBMED 16154587

About this Structure

2AUK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit., Chlenov M, Masuda S, Murakami KS, Nikiforov V, Darst SA, Mustaev A, J Mol Biol. 2005 Oct 14;353(1):138-54. PMID:16154587

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