2avf

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{{STRUCTURE_2avf| PDB=2avf | SCENE= }}
{{STRUCTURE_2avf| PDB=2avf | SCENE= }}
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'''Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes'''
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===Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes===
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==Overview==
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Monoclinic crystal structure of C-terminal desundecapeptide nitrite reductase (NiRc-11) from Achromobacter cycloclastes was determined at 2.6A. NiRc-11 exists as a loose trimer in the crystal. Deletion of 11 residues eliminates all intersubunit hydrogen bonds mediated by the C-terminal tail. The rigid irregular coil 105-112, which constitutes part of the sidewall of the active site pocket, undergoes conformational changes and becomes highly flexible in NiRc-11. Correspondingly, the linker segments between the two copper sites 95-100 and 135-136 are partly relaxed in conformation, which leads to disrupted active site microenvironments responsible for the activity loss and spectral change of NiRc-11. Comparison with the native structure revealed a bulky residue Met331 fastened by hydrogen bonding, which may play a direct role in keeping the right copper site geometry by protruding its side chain against the irregular coil 105-112. Sequence alignment showed that the bulky residue is conserved at position 331, indicating an equal importance of C-terminal segment in other copper-containing nitrite reductases.
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(as it appears on PubMed at http://www.pubmed.gov), where 16293231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16293231}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, J P.]]
[[Category: Zhang, J P.]]
[[Category: Beta barrel trimer]]
[[Category: Beta barrel trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:31:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:54:17 2008''

Revision as of 07:54, 29 July 2008

Image:2avf.png

Template:STRUCTURE 2avf

Crystal Structure of C-terminal Desundecapeptide Nitrite Reductase from Achromobacter cycloclastes

Template:ABSTRACT PUBMED 16293231

About this Structure

2AVF is a Single protein structure of sequence from Achromobacter cycloclastes. Full crystallographic information is available from OCA.

Reference

Crystal structure of C-terminal desundecapeptide nitrite reductase from Achromobacter cycloclastes., Li HT, Chang T, Chang WC, Chen CJ, Liu MY, Gui LL, Zhang JP, An XM, Chang WR, Biochem Biophys Res Commun. 2005 Dec 30;338(4):1935-42. Epub 2005 Nov 15. PMID:16293231

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