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2ax1

From Proteopedia

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{{STRUCTURE_2ax1| PDB=2ax1 | SCENE= }}
{{STRUCTURE_2ax1| PDB=2ax1 | SCENE= }}
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'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)'''
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===Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)===
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==Overview==
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Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.
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(as it appears on PubMed at http://www.pubmed.gov), where 16451069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16451069}}
==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:34:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:21:41 2008''

Revision as of 01:21, 28 July 2008

Image:2ax1.png

Template:STRUCTURE 2ax1

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)

Template:ABSTRACT PUBMED 16451069

About this Structure

2AX1 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:16451069

Page seeded by OCA on Mon Jul 28 04:21:41 2008

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