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2axw

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[[Image:2axw.jpg|left|200px]]
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{{STRUCTURE_2axw| PDB=2axw | SCENE= }}
{{STRUCTURE_2axw| PDB=2axw | SCENE= }}
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'''Structure of DraD invasin from uropathogenic Escherichia coli'''
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===Structure of DraD invasin from uropathogenic Escherichia coli===
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==Overview==
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The dra gene cluster of uropathogenic strains of Escherichia coli produces proteins involved in bacterial attachment to and invasion of the eukaryotic host tissues. The crystal structure of a construct of E. coli DraD possessing an additional C-terminal extension of 13 amino acids, including a His6 tag, has been solved at a resolution of 1.05 angstroms. The protein forms symmetric dimers through the exchange of the C-terminal beta-strands, which participate in the immunoglobulin-like beta-sandwich fold of each subunit. This structure confirms that DraD is able to act as an acceptor in the donor-strand complementation mechanism of fiber formation but, in contrast to DraE adhesin, its native sequence does not have a donor strand; therefore, DraD can only be located at the tip of the fiber.
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(as it appears on PubMed at http://www.pubmed.gov), where 16421447 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16421447}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin-like fold]]
[[Category: Immunoglobulin-like fold]]
[[Category: Swapped c-terminal strand]]
[[Category: Swapped c-terminal strand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:36:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:20:26 2008''

Revision as of 10:20, 28 July 2008

Template:STRUCTURE 2axw

Structure of DraD invasin from uropathogenic Escherichia coli

Template:ABSTRACT PUBMED 16421447

About this Structure

2AXW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of DraD invasin from uropathogenic Escherichia coli: a dimer with swapped beta-tails., Jedrzejczak R, Dauter Z, Dauter M, Piatek R, Zalewska B, Mroz M, Bury K, Nowicki B, Kur J, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):157-64. Epub 2006, Jan 18. PMID:16421447

Page seeded by OCA on Mon Jul 28 13:20:26 2008

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