2ayn

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[[Image:2ayn.gif|left|200px]]
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{{STRUCTURE_2ayn| PDB=2ayn | SCENE= }}
{{STRUCTURE_2ayn| PDB=2ayn | SCENE= }}
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'''Structure of USP14, a proteasome-associated deubiquitinating enzyme'''
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===Structure of USP14, a proteasome-associated deubiquitinating enzyme===
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==Overview==
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The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. Mammalian USP14 (Ubp6 in yeast) is unique among known UBP enzymes in that it is activated catalytically upon specific association with the 26S proteasome. Here, we report the crystal structures of the 45-kDa catalytic domain of USP14 in isolation and in a complex with ubiquitin aldehyde, which reveal distinct structural features. In the absence of ubiquitin binding, the catalytic cleft leading to the active site of USP14 is blocked by two surface loops. Binding by ubiquitin induces a significant conformational change that translocates the two surface loops thereby allowing access of the ubiquitin C-terminus to the active site. These structural observations, in conjunction with biochemical characterization, identify important regulatory mechanisms for USP14.
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(as it appears on PubMed at http://www.pubmed.gov), where 16211010 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16211010}}
==About this Structure==
==About this Structure==
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[[Category: Proteasome]]
[[Category: Proteasome]]
[[Category: Usp14]]
[[Category: Usp14]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:37:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:27:59 2008''

Revision as of 05:28, 28 July 2008

Image:2ayn.png

Template:STRUCTURE 2ayn

Structure of USP14, a proteasome-associated deubiquitinating enzyme

Template:ABSTRACT PUBMED 16211010

About this Structure

2AYN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14., Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y, EMBO J. 2005 Nov 2;24(21):3747-56. Epub 2005 Oct 6. PMID:16211010

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