This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2az5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2az5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2az5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2az5| PDB=2az5 | SCENE= }}
{{STRUCTURE_2az5| PDB=2az5 | SCENE= }}
-
'''Crystal Structure of TNF-alpha with a small molecule inhibitor'''
+
===Crystal Structure of TNF-alpha with a small molecule inhibitor===
-
==Overview==
+
<!--
-
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and cell-based assays with median inhibitory concentrations of 22 and 4.6 micromolar, respectively. Formation of an intermediate complex between the compound and the intact trimer results in a 600-fold accelerated subunit dissociation rate that leads to trimer dissociation. A structure solved by x-ray crystallography reveals that a single compound molecule displaces a subunit of the trimer to form a complex with a dimer of TNF-alpha subunits.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16284179}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16284179 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16284179}}
==About this Structure==
==About this Structure==
Line 24: Line 28:
[[Category: He, M M.]]
[[Category: He, M M.]]
[[Category: Tnf-alpha trimer disruption by binding of a small molecule inhibitor]]
[[Category: Tnf-alpha trimer disruption by binding of a small molecule inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:39:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:03:27 2008''

Revision as of 11:03, 27 July 2008

Image:2az5.png

Template:STRUCTURE 2az5

Crystal Structure of TNF-alpha with a small molecule inhibitor

Template:ABSTRACT PUBMED 16284179

About this Structure

2AZ5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Small-molecule inhibition of TNF-alpha., He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC, Science. 2005 Nov 11;310(5750):1022-5. PMID:16284179

Page seeded by OCA on Sun Jul 27 14:03:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2az5"
Personal tools