2azl

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[[Image:2azl.gif|left|200px]]
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{{STRUCTURE_2azl| PDB=2azl | SCENE= }}
{{STRUCTURE_2azl| PDB=2azl | SCENE= }}
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'''Crystal structure for the mutant F117E of Thermotoga maritima octaprenyl pyrophosphate synthase'''
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===Crystal structure for the mutant F117E of Thermotoga maritima octaprenyl pyrophosphate synthase===
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==Overview==
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Hexaprenyl pyrophosphate synthase (HexPPs) from Sulfolobus solfataricus catalyzes the synthesis of trans-C(30)-hexaprenyl pyrophosphate (HexPP) by reacting two isopentenyl pyrophosphate molecules with one geranylgeranyl pyrophosphate. The crystal structure of the homodimeric C(30)-HexPPs resembles those of other trans-prenyltransferases, including farnesyl pyrophosphate synthase (FPPs) and octaprenyl pyrophosphate synthase (OPPs). In both subunits, 10 core helices are arranged about a central active site cavity. Leu164 in the middle of the cavity controls the product chain length. Two protein conformers are observed in the S. solfataricus HexPPs structure, and the major difference between them occurs in the flexible region of residues 84 to 100. Several helices (alphaI, alphaJ, alphaK, and part of alphaH) and the associated loops have high-temperature factors in one monomer, which may be related to the domain motion that controls the entrance to the active site. Different side chain conformations of Trp136 in two HexPPs subunits result in weaker hydrophobic interactions at the dimer interface, in contrast to the symmetric pi-pi stacking interactions of aromatic side chains found in FPPs and OPPs. Finally, the three-conformer switched model may explain the catalytic process for HexPPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 16291686 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16291686}}
==About this Structure==
==About this Structure==
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[[Category: Opp]]
[[Category: Opp]]
[[Category: Trans-prenyltransferase]]
[[Category: Trans-prenyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:39:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:59:43 2008''

Revision as of 05:59, 28 July 2008

Image:2azl.png

Template:STRUCTURE 2azl

Crystal structure for the mutant F117E of Thermotoga maritima octaprenyl pyrophosphate synthase

Template:ABSTRACT PUBMED 16291686

About this Structure

2AZL is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures., Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH, J Bacteriol. 2005 Dec;187(23):8137-48. PMID:16291686

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