2azr

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[[Image:2azr.gif|left|200px]]
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{{STRUCTURE_2azr| PDB=2azr | SCENE= }}
{{STRUCTURE_2azr| PDB=2azr | SCENE= }}
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'''Crystal structure of PTP1B with Bicyclic Thiophene inhibitor'''
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===Crystal structure of PTP1B with Bicyclic Thiophene inhibitor===
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==Overview==
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A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16303309}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolyase]]
[[Category: Hydrolyase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:40:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:25:25 2008''

Revision as of 13:25, 27 July 2008

Image:2azr.png

Template:STRUCTURE 2azr

Crystal structure of PTP1B with Bicyclic Thiophene inhibitor

Template:ABSTRACT PUBMED 16303309

About this Structure

2AZR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:16303309

Page seeded by OCA on Sun Jul 27 16:25:25 2008

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