1a25

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(New page: 200px<br /> <applet load="1a25" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a25, resolution 2.70&Aring;" /> '''C2 DOMAIN FROM PROT...)
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==About this Structure==
==About this Structure==
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1A25 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA and PSE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A25 OCA]].
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1A25 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA and PSE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: CLB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A25 OCA]].
==Reference==
==Reference==
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[[Category: calcium-binding protein]]
[[Category: calcium-binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:51:53 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:08:33 2007''

Revision as of 10:03, 30 October 2007


1a25, resolution 2.70Å

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C2 DOMAIN FROM PROTEIN KINASE C (BETA)

Overview

BACKGROUND: Conventional isoforms (alpha, beta and gamma) of protein, kinase C (PKC) are synergistically activated by phosphatidylserine and, Ca2+; both bind to C2 domains located within the PKC amino-terminal, regulatory regions. C2 domains contain a bipartite or tripartite, Ca2+-binding site formed by opposing loops at one end of the protein., Neither the structural basis for cooperativity between phosphatidylserine, and Ca2+, nor the binding site for phosphatidylserine are known. RESULTS:, The structure of the C2 domain from PKCbeta complexed with Ca2+ and, o-phospho-L-serine has been determined to 2.7 A resolution using X-ray, crystallography. The eight-stranded, Greek key beta-sandwich fold of, PKCbeta-C2 is similar to that of the synaptotagmin I type I C2 domain., Three Ca2+ ions, ... [(full description)]

About this Structure

1A25 is a [Single protein] structure of sequence from [Rattus norvegicus] with CA and PSE as [ligands]. Structure known Active Site: CLB. Full crystallographic information is available from [OCA].

Reference

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+., Sutton RB, Sprang SR, Structure. 1998 Nov 15;6(11):1395-405. PMID:9817842

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