2b0u

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{{STRUCTURE_2b0u| PDB=2b0u | SCENE= }}
{{STRUCTURE_2b0u| PDB=2b0u | SCENE= }}
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'''The Structure of the Follistatin:Activin Complex'''
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===The Structure of the Follistatin:Activin Complex===
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==Overview==
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TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are essential regulators of physiological responses. Here we report the structure of activin A, a TGF-beta ligand, bound to the high-affinity antagonist follistatin. Two follistatin molecules encircle activin, neutralizing the ligand by burying one-third of its residues and its receptor binding sites. Previous studies have suggested that type I receptor binding would not be blocked by follistatin, but the crystal structure reveals that the follistatin N-terminal domain has an unexpected fold that mimics a universal type I receptor motif and occupies this receptor binding site. The formation of follistatin:BMP:type I receptor complexes can be explained by the stoichiometric and geometric arrangement of the activin:follistatin complex. The mode of ligand binding by follistatin has important implications for its ability to neutralize homo- and heterodimeric ligands of this growth factor family.
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{{ABSTRACT_PUBMED_16198295}}
==Disease==
==Disease==
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[[Category: Morphogen]]
[[Category: Morphogen]]
[[Category: Tgf-beta]]
[[Category: Tgf-beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:42:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:18:48 2008''

Revision as of 14:18, 27 July 2008

Image:2b0u.png

Template:STRUCTURE 2b0u

Contents

The Structure of the Follistatin:Activin Complex

Template:ABSTRACT PUBMED 16198295

Disease

Known disease associated with this structure: Polycystic ovary syndrome OMIM:[136470]

About this Structure

2B0U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding., Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS, Dev Cell. 2005 Oct;9(4):535-43. PMID:16198295

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