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2b11

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[[Image:2b11.gif|left|200px]]
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{{STRUCTURE_2b11| PDB=2b11 | SCENE= }}
{{STRUCTURE_2b11| PDB=2b11 | SCENE= }}
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'''Crystal structure of the protein-protein complex between F82W cytochrome c and cytochrome c peroxidase'''
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===Crystal structure of the protein-protein complex between F82W cytochrome c and cytochrome c peroxidase===
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==Overview==
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Although bonding networks determine electron-transfer (ET) rates within proteins, the mechanism by which structure and dynamics influence ET across protein interfaces is not well understood. Measurements of photochemically induced ET and subsequent charge recombination between Zn-porphyrin-substituted cytochrome c peroxidase and cytochrome c in single crystals correlate reactivity with defined structures for different association modes of the redox partners. Structures and ET rates in crystals are consistent with tryptophan oxidation mediating charge recombination reactions. Conservative mutations at the interface can drastically affect how the proteins orient and dispose redox centers. Whereas some configurations are ET inactive, the wild-type complex exhibits the fastest recombination rate. Other association modes generate ET rates that do not correlate with predictions based on cofactor separations or simple bonding pathways. Inhibition of photoinduced ET at &lt;273 K indicates gating by small-amplitude dynamics, even within the crystal. Thus, different associations achieve states of similar reactivity, and within those states conformational fluctuations enable interprotein ET.
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The line below this paragraph, {{ABSTRACT_PUBMED_16227441}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16227441 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16227441}}
==About this Structure==
==About this Structure==
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[[Category: Cytochrome]]
[[Category: Cytochrome]]
[[Category: Electron transfer]]
[[Category: Electron transfer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:43:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:09:14 2008''

Revision as of 20:09, 27 July 2008

Image:2b11.png

Template:STRUCTURE 2b11

Crystal structure of the protein-protein complex between F82W cytochrome c and cytochrome c peroxidase

Template:ABSTRACT PUBMED 16227441

About this Structure

2B11 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Effects of interface mutations on association modes and electron-transfer rates between proteins., Kang SA, Crane BR, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15465-70. Epub 2005 Oct 14. PMID:16227441

Page seeded by OCA on Sun Jul 27 23:09:14 2008

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