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| - | [[Image:2b15.gif|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_2b15| PDB=2b15 | SCENE= }} | | {{STRUCTURE_2b15| PDB=2b15 | SCENE= }} |
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| - | '''The crystal structure of 2,4-dinitrophenol in complex with human transthyretin'''
| + | ===The crystal structure of 2,4-dinitrophenol in complex with human transthyretin=== |
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| - | ==Overview==
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| - | Systemic deposition of transthyretin (TTR) amyloid fibrils is always observed in familial amyloidotic polyneuropathy, senile systemic amyloidosis and familial amyloidotic cardiomyopathy patients. Destabilization of the molecule leads to a cascade of events which result in fibril formation. The destabilization of a native protein with consequent conformational changes appears to be a common link in several human amyloid diseases. Intensive research has been directed towards finding small molecules that could work as therapeutic agents for the prevention/inhibition of amyloid diseases through stabilization of the native fold of the potentially amyloidogenic protein. This work provides insight into the structural determinants of the highly stabilizing effects of 2,4-dinitrophenol on wild-type TTR. It is also shown that similar interactions are established between this molecule and two highly amyloidogenic TTR variants: TTR L55P and TTR Y78F. In the three crystal complexes, 2,4-dinitrophenol occupies the two hormone-binding sites of the TTR tetramer. As a result of 2,4-dinitrophenol binding, the two dimers in the TTR tetramer become closer, increasing the stability of the protein. The three-dimensional structures now determined allow a comprehensive description of key interactions between transthyretin and 2,4-dinitrophenol, a small compound that holds promise as a template for the design of a therapeutical drug for amyloid diseases.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_16627944}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 16627944 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_16627944}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Tetramer stabilizer]] | | [[Category: Tetramer stabilizer]] |
| | [[Category: Transthyretin]] | | [[Category: Transthyretin]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:43:26 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:50:59 2008'' |
Revision as of 03:51, 28 July 2008
Template:STRUCTURE 2b15
The crystal structure of 2,4-dinitrophenol in complex with human transthyretin
Template:ABSTRACT PUBMED 16627944
About this Structure
2B15 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin., Morais-de-Sa E, Neto-Silva RM, Pereira PJ, Saraiva MJ, Damas AM, Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):512-9. Epub 2006, Apr 19. PMID:16627944
Page seeded by OCA on Mon Jul 28 06:50:59 2008
