2b1a

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{{Seed}}
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{{STRUCTURE_2b1a| PDB=2b1a | SCENE= }}
{{STRUCTURE_2b1a| PDB=2b1a | SCENE= }}
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'''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide'''
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===Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide===
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==Overview==
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Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
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(as it appears on PubMed at http://www.pubmed.gov), where 16731948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16731948}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: V3 loop]]
[[Category: V3 loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:43:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:48:33 2008''

Revision as of 11:48, 28 July 2008

Image:2b1a.png

Template:STRUCTURE 2b1a

Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide

Template:ABSTRACT PUBMED 16731948

About this Structure

2B1A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:16731948

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