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2b22

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{{STRUCTURE_2b22| PDB=2b22 | SCENE= }}
{{STRUCTURE_2b22| PDB=2b22 | SCENE= }}
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'''Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat'''
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===Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat===
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==Overview==
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Coiled-coil sequences in proteins commonly share a seven-amino acid repeat with nonpolar side chains at the first (a) and fourth (d) positions. We investigate here the role of a 3-3-1 hydrophobic repeat containing nonpolar amino acids at the a, d, and g positions in determining the structures of coiled coils using mutants of the GCN4 leucine zipper dimerization domain. When three charged residues at the g positions in the parental sequence are replaced by nonpolar alanine or valine side chains, stable four-helix structures result. The X-ray crystal structures of the tetramers reveal antiparallel, four-stranded coiled coils in which the a, d, and g side chains interlock in a combination of knobs-into-knobs and knobs-into-holes packing. Interfacial interactions in a coiled coil can therefore be prescribed by hydrophobic-polar patterns beyond the canonical 3-4 heptad repeat. The results suggest that the conserved, charged residues at the g positions in the GCN4 leucine zipper can impart a negative design element to disfavor thermodynamically more stable, antiparallel tetramers.
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(as it appears on PubMed at http://www.pubmed.gov), where 16472744 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16472744}}
==About this Structure==
==About this Structure==
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[[Category: Protein design]]
[[Category: Protein design]]
[[Category: Protein structure]]
[[Category: Protein structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:45:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:31:50 2008''

Revision as of 06:31, 28 July 2008

Image:2b22.png

Template:STRUCTURE 2b22

Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat

Template:ABSTRACT PUBMED 16472744

About this Structure

2B22 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat., Deng Y, Liu J, Zheng Q, Eliezer D, Kallenbach NR, Lu M, Structure. 2006 Feb;14(2):247-55. PMID:16472744

Page seeded by OCA on Mon Jul 28 09:31:50 2008

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