2b2c

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{{STRUCTURE_2b2c| PDB=2b2c | SCENE= }}
{{STRUCTURE_2b2c| PDB=2b2c | SCENE= }}
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'''Cloning, expression, characterisation and three- dimensional structure determination of the Caenorhabditis elegans spermidine synthase'''
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===Cloning, expression, characterisation and three- dimensional structure determination of the Caenorhabditis elegans spermidine synthase===
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==Overview==
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The polyamine synthesis enzyme spermidine synthase (SPDS) has been cloned from the model nematode Caenorhabditis elegans. Biochemical characterisation of the recombinantly expressed protein revealed a high degree of similarity to other eukaryotic SPDS with the exception of a low affinity towards the substrate decarboxylated S-adenosylmethionine (Km = 110 microM) and a less pronounced feedback inhibition by the second reaction product 5'-methylthioadenosine (IC50 = 430 microM). The C. elegans protein that carries a nematode-specific insertion of 27 amino acids close to its N-terminus was crystallized, leading to the first X-ray structure of a dimeric eukaryotic SPDS.
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(as it appears on PubMed at http://www.pubmed.gov), where 16226262 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16226262}}
==About this Structure==
==About this Structure==
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[[Category: Walter, R D.]]
[[Category: Walter, R D.]]
[[Category: Beta-alpha]]
[[Category: Beta-alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:35:36 2008''

Revision as of 00:35, 29 July 2008

Image:2b2c.png

Template:STRUCTURE 2b2c

Cloning, expression, characterisation and three- dimensional structure determination of the Caenorhabditis elegans spermidine synthase

Template:ABSTRACT PUBMED 16226262

About this Structure

2B2C is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase., Dufe VT, Luersen K, Eschbach ML, Haider N, Karlberg T, Walter RD, Al-Karadaghi S, FEBS Lett. 2005 Nov 7;579(27):6037-43. Epub 2005 Oct 5. PMID:16226262

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