2b3h

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{{STRUCTURE_2b3h| PDB=2b3h | SCENE= }}
{{STRUCTURE_2b3h| PDB=2b3h | SCENE= }}
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'''Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site'''
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===Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site===
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==Overview==
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Determination of the crystal structure of human MetAP1 makes it possible, for the first time, to compare the structures of a Type I and a Type II methionine aminopeptidase (MetAP) from the same organism. Comparison of the Type I enzyme with the previously reported complex of ovalicin with Type II MetAP shows that the active site of the former is reduced in size and would incur steric clashes with the bound inhibitor. This explains why ovalicin and related anti-angiogenesis inhibitors target Type II human MetAP but not Type I. The differences in both size and shape of the active sites between MetAP1 and MetAP2 also help to explain their different substrate specificity. In the presence of excess Co(2+), a third cobalt ion binds in the active site region, explaining why metal ions in excess can be inhibitory. Also, the N-terminal region of the protein contains three distinct Pro-x-x-Pro motifs, supporting the prior suggestion that this region of the protein may participate in binding to the ribosome.
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The line below this paragraph, {{ABSTRACT_PUBMED_16274222}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16274222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16274222}}
==About this Structure==
==About this Structure==
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[[Category: Methionine aminopeptidase]]
[[Category: Methionine aminopeptidase]]
[[Category: Pitabread fold]]
[[Category: Pitabread fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:48:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:51:22 2008''

Revision as of 16:51, 27 July 2008

Image:2b3h.png

Template:STRUCTURE 2b3h

Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site

Template:ABSTRACT PUBMED 16274222

About this Structure

2B3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the functional differences between type I and type II human methionine aminopeptidases., Addlagatta A, Hu X, Liu JO, Matthews BW, Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222

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