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2b3y

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[[Image:2b3y.gif|left|200px]]
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[[Image:2b3y.png|left|200px]]
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==Overview==
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{{ABSTRACT_16407072}}
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Iron regulatory proteins (IRPs) control the translation of proteins involved in iron uptake, storage and utilization by binding to specific noncoding sequences of the corresponding mRNAs known as iron-responsive elements (IREs). This strong interaction assures proper iron homeostasis in animal cells under iron shortage. Conversely, under iron-replete conditions, IRP1 binds a [4Fe-4S] cluster and functions as cytosolic aconitase. Regulation of the balance between the two IRP1 activities is complex, and it does not depend only on iron availability. Here, we report the crystal structure of human IRP1 in its aconitase form. Comparison with known structures of homologous enzymes reveals well-conserved folds and active site environments with significantly different surface shapes and charge distributions. The specific features of human IRP1 allow us to propose a tentative model of an IRP1-IRE complex that agrees with a range of previously obtained data.
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==About this Structure==
==About this Structure==
2B3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2B3Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3Y OCA].
2B3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2B3Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3Y OCA].
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==Reference==
 
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Crystal structure of human iron regulatory protein 1 as cytosolic aconitase., Dupuy J, Volbeda A, Carpentier P, Darnault C, Moulis JM, Fontecilla-Camps JC, Structure. 2006 Jan;14(1):129-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16407072 16407072]
 
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Aconitate hydratase]]
[[Category: Aconitate hydratase]]
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[[Category: Volbeda, A.]]
[[Category: Volbeda, A.]]
[[Category: Irp1 ire-irp1 aconitase activity]]
[[Category: Irp1 ire-irp1 aconitase activity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:49:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:12:22 2008''

Revision as of 15:12, 26 June 2008

Image:2b3y.png

Template:STRUCTURE 2b3y

Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)


Template:ABSTRACT 16407072

About this Structure

2B3Y is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 2B3Y with [Aconitase and Iron Regulatory Protein 1]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:12:22 2008

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