2b53

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[[Image:2b53.gif|left|200px]]
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{{STRUCTURE_2b53| PDB=2b53 | SCENE= }}
{{STRUCTURE_2b53| PDB=2b53 | SCENE= }}
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'''Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325'''
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===Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325===
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==Overview==
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Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
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(as it appears on PubMed at http://www.pubmed.gov), where 11354366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11354366}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:06:24 2008''

Revision as of 11:06, 29 July 2008

Template:STRUCTURE 2b53

Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325

Template:ABSTRACT PUBMED 11354366

About this Structure

2B53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Quinazolines as cyclin dependent kinase inhibitors., Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60. PMID:11354366

Page seeded by OCA on Tue Jul 29 14:06:24 2008

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