2b5a

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{{STRUCTURE_2b5a| PDB=2b5a | SCENE= }}
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'''C.BclI, Control Element of the BclI Restriction-Modification System'''
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===C.BclI, Control Element of the BclI Restriction-Modification System===
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==Overview==
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Protection from DNA invasion is afforded by restriction-modification systems in many bacteria. The efficiency of protection depends crucially on the relative expression levels of restriction versus methytransferase genes. This regulation is provided by a controller protein, named C protein. Studies of the Bcll system in E. coli suggest that C.Bcll functions as a negative regulator for M.Bcll expression, implying that it plays a role in defense against foreign DNA during virus infection. C.Bcll binds (Kd = 14.3 nM) to a 2-fold symmetric C box DNA sequence that overlaps with the putative -35 promoter region upstream of the bcllM and bcllC genes. The C.Bcll fold comprises five alpha helices: two helices form a helix-turn-helix motif, and the remaining three helices form the extensive dimer interface. The C.Bcll-DNA model proposed suggests that DNA bending might play an important role in gene regulation, and that Glu27 and Asp31 in C.Bcll might function critically in the regulation.
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{{ABSTRACT_PUBMED_16338412}}
==About this Structure==
==About this Structure==
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[[Category: Zhu, Z.]]
[[Category: Zhu, Z.]]
[[Category: Helix-turn-helix motif]]
[[Category: Helix-turn-helix motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:23:10 2008''

Revision as of 04:23, 29 July 2008

Image:2b5a.png

Template:STRUCTURE 2b5a

C.BclI, Control Element of the BclI Restriction-Modification System

Template:ABSTRACT PUBMED 16338412

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the restriction-modification system control element C.Bcll and mapping of its binding site., Sawaya MR, Zhu Z, Mersha F, Chan SH, Dabur R, Xu SY, Balendiran GK, Structure. 2005 Dec;13(12):1837-47. PMID:16338412

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