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2b5l

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{{STRUCTURE_2b5l| PDB=2b5l | SCENE= }}
{{STRUCTURE_2b5l| PDB=2b5l | SCENE= }}
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'''Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein'''
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===Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein===
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==Overview==
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The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 16413485 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16413485}}
==About this Structure==
==About this Structure==
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[[Category: Sv5-v]]
[[Category: Sv5-v]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:53:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:40:37 2008''

Revision as of 12:40, 29 July 2008

Image:2b5l.png

Template:STRUCTURE 2b5l

Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein

Template:ABSTRACT PUBMED 16413485

About this Structure

2B5L is a Protein complex structure of sequences from Homo sapiens and Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485

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