2b6o

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[[Image:2b6o.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2b6o| PDB=2b6o | SCENE= }}
{{STRUCTURE_2b6o| PDB=2b6o | SCENE= }}
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'''electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state'''
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===electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state===
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==Overview==
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Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals. Comparison of junctional and non-junctional AQP0 structures shows that junction formation depends on a conformational switch in an extracellular loop, which may result from cleavage of the cytoplasmic amino and carboxy termini. In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other. Packing interactions between AQP0 tetramers in the crystalline array are mediated by lipid molecules, which assume preferred conformations. We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 16319884 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16319884}}
==About this Structure==
==About this Structure==
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[[Category: Lipid-protein interaction]]
[[Category: Lipid-protein interaction]]
[[Category: Membrane]]
[[Category: Membrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:55:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:47:06 2008''

Revision as of 05:47, 28 July 2008

Image:2b6o.png

Template:STRUCTURE 2b6o

electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state

Template:ABSTRACT PUBMED 16319884

About this Structure

2B6O is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:16319884

Page seeded by OCA on Mon Jul 28 08:47:06 2008

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