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2b7y

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[[Image:2b7y.gif|left|200px]]
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{{Seed}}
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[[Image:2b7y.png|left|200px]]
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{{STRUCTURE_2b7y| PDB=2b7y | SCENE= }}
{{STRUCTURE_2b7y| PDB=2b7y | SCENE= }}
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'''Fava Bean Lectin-Glucose Complex'''
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===Fava Bean Lectin-Glucose Complex===
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==Overview==
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The three-dimensional structure of favin, the glucose- and mannose-binding lectin of Vicia faba (vetch, broad bean), has been determined at a resolution of 2.8 angstroms by molecular replacement. The crystals contain specifically bound glucose and provide the first high-resolution view of specific saccharide binding in a leguminous lectin. The structure is similar to those of concanavalin A (Con A) and green pea lectin; differences from Con A show that minimal changes are needed to accommodate the cyclic permutation in amino acid sequence between the two molecules. The molecule is an ellipsoidal dimer dominated by extensive beta structures. Each protomer contains binding sites for two divalent metal ions (Mn2+ and Ca2+) and a specific saccharide. Glucose is bound by favin in a cleft in the molecular surface and has noncovalent contacts primarily with two peptide loops, one of which contains several metal ion ligands. The specific carbohydrate-binding site is similar to that of Con A in location and general peptide folding, despite several differences in specific amino acid residues.
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The line below this paragraph, {{ABSTRACT_PUBMED_3775378}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3775378 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3775378}}
==About this Structure==
==About this Structure==
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[[Category: Plant lectin]]
[[Category: Plant lectin]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:58:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:55:25 2008''

Revision as of 17:55, 28 July 2008

Image:2b7y.png

Template:STRUCTURE 2b7y

Fava Bean Lectin-Glucose Complex

Template:ABSTRACT PUBMED 3775378

About this Structure

2B7Y is a Protein complex structure of sequences from Vicia faba. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of favin: saccharide binding-cyclic permutation in leguminous lectins., Reeke GN Jr, Becker JW, Science. 1986 Nov 28;234(4780):1108-11. PMID:3775378

Page seeded by OCA on Mon Jul 28 20:55:25 2008

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