This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2b8l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2b8l.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2b8l.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b8l| PDB=2b8l | SCENE= }}
{{STRUCTURE_2b8l| PDB=2b8l | SCENE= }}
-
'''Crystal structure of human beta secretase complexed with inhibitor'''
+
===Crystal structure of human beta secretase complexed with inhibitor===
-
==Overview==
+
<!--
-
We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16263281}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16263281 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16263281}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Bace]]
[[Category: Bace]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:59:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:43:34 2008''

Revision as of 09:43, 27 July 2008

Template:STRUCTURE 2b8l

Crystal structure of human beta secretase complexed with inhibitor

Template:ABSTRACT PUBMED 16263281

About this Structure

2B8L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformationally biased P3 amide replacements of beta-secretase inhibitors., Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2. PMID:16263281

Page seeded by OCA on Sun Jul 27 12:43:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools