2b9r

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{{STRUCTURE_2b9r| PDB=2b9r | SCENE= }}
{{STRUCTURE_2b9r| PDB=2b9r | SCENE= }}
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'''Crystal Structure of Human Cyclin B1'''
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===Crystal Structure of Human Cyclin B1===
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==Overview==
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Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate specificity of cdk1, and destruction of cyclin B is necessary for mitotic exit. Overexpression of human cyclin B1 has been found in numerous cancers and has been associated with tumor aggressiveness. Here we report the crystal structure of human cyclin B1 to 2.9 A. Comparison of the structure with cyclin A and cyclin E reveals remarkably similar N-terminal cyclin box motifs but significant differences among the C-terminal cyclin box lobes. Divergence in sequence gives rise to unique interaction surfaces at the proposed cyclin B/cdk1 interface as well as the 'RxL' motif substrate binding site on cyclin B. Examination of the structure provides insight into the molecular basis for differential affinities of protein based cyclin/cdk inhibitors such as p27, substrate recognition, and cdk interaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_17495533}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17495533 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17495533}}
==About this Structure==
==About this Structure==
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[[Category: Petri, E.]]
[[Category: Petri, E.]]
[[Category: Cyclin]]
[[Category: Cyclin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:01:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:47:53 2008''

Revision as of 13:47, 28 July 2008

Image:2b9r.png

Template:STRUCTURE 2b9r

Crystal Structure of Human Cyclin B1

Template:ABSTRACT PUBMED 17495533

About this Structure

2B9R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human cyclin B., Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R, Cell Cycle. 2007 Jun 1;6(11):1342-9. Epub 2007 Jun 14. PMID:17495533

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