2bab

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[[Image:2bab.gif|left|200px]]
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{{Seed}}
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[[Image:2bab.png|left|200px]]
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{{STRUCTURE_2bab| PDB=2bab | SCENE= }}
{{STRUCTURE_2bab| PDB=2bab | SCENE= }}
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'''Crystal structure of CLA-producing fatty acid isomerase from P. acnes'''
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===Crystal structure of CLA-producing fatty acid isomerase from P. acnes===
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==Overview==
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Conjugated linoleic acids (CLAs) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. Several isomers of CLA exist, of which the (9Z, 11E) and (10E, 12Z) isomers have beneficial effects on human metabolism but are scarce in foods. Bacterial polyunsaturated fatty acid isomerases are promising biotechnological catalysts for CLA production. We describe six crystal structures of the Propionibacterium acnes polyunsaturated fatty acid isomerase PAI in apo- and product-bound forms. The three-domain flavoprotein has previously undescribed folds outside the FAD-binding site. Conformational changes in a hydrophobic channel toward the active site reveal a unique gating mechanism for substrate specificity. The geometry of the substrate-binding site explains the length preferences for C18 fatty acids. A catalytic mechanism for double-bond isomerization is formulated that may be altered to change substrate specificity for syntheses of rare CLAs from easily accessible precursors.
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The line below this paragraph, {{ABSTRACT_PUBMED_16477020}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16477020 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16477020}}
==About this Structure==
==About this Structure==
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[[Category: Fad]]
[[Category: Fad]]
[[Category: Isomerase]]
[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:02:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:09:26 2008''

Revision as of 05:09, 28 July 2008

Image:2bab.png

Template:STRUCTURE 2bab

Crystal structure of CLA-producing fatty acid isomerase from P. acnes

Template:ABSTRACT PUBMED 16477020

About this Structure

2BAB is a Single protein structure of sequence from Propionibacterium acnes. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase., Liavonchanka A, Hornung E, Feussner I, Rudolph MG, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2576-81. Epub 2006 Feb 13. PMID:16477020

Page seeded by OCA on Mon Jul 28 08:09:26 2008

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