2bbu

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[[Image:2bbu.gif|left|200px]]
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[[Image:2bbu.png|left|200px]]
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{{STRUCTURE_2bbu| PDB=2bbu | SCENE= }}
{{STRUCTURE_2bbu| PDB=2bbu | SCENE= }}
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'''solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor'''
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===solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor===
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==Overview==
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SOCS3 is essential for regulating the extent, duration, and specificity of cellular responses to cytokines such as G-CSF and IL-6. Here we describe the solution structure of SOCS3, the first structure determined for any SOCS protein, in complex with a phosphotyrosine-containing peptide from the IL-6 receptor signaling subunit gp130. The structure of the complex shows that seven peptide residues form a predominantly hydrophobic binding motif. Regions outside the SOCS3 SH2 domain are important for ligand binding, in particular, a single 15 residue alpha helix immediately N-terminal to the SH2 domain makes direct contacts with the phosphotyrosine binding loop and, in part, determines its geometry. The SH2 domain itself is remarkable in that it contains a 35 residue unstructured PEST motif insertion that is not required for STAT inhibition. The PEST motif increases SOCS3 turnover and affects its degradation pathway, implying that it has an important regulatory role inside the cell.
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The line below this paragraph, {{ABSTRACT_PUBMED_16630890}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16630890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16630890}}
==About this Structure==
==About this Structure==
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2BBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBU OCA].
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2BBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBU OCA].
==Reference==
==Reference==
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:49:27 2008''

Revision as of 02:49, 29 July 2008

Image:2bbu.png

Template:STRUCTURE 2bbu

solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor

Template:ABSTRACT PUBMED 16630890

About this Structure

2BBU is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability., Babon JJ, McManus EJ, Yao S, DeSouza DP, Mielke LA, Sprigg NS, Willson TA, Hilton DJ, Nicola NA, Baca M, Nicholson SE, Norton RS, Mol Cell. 2006 Apr 21;22(2):205-16. PMID:16630890

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