2bcx

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[[Image:2bcx.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2bcx| PDB=2bcx | SCENE= }}
{{STRUCTURE_2bcx| PDB=2bcx | SCENE= }}
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'''Crystal structure of calmodulin in complex with a ryanodine receptor peptide'''
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===Crystal structure of calmodulin in complex with a ryanodine receptor peptide===
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==Overview==
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Calmodulin regulates ryanodine receptor-mediated Ca(2+) release through a conserved binding site. The crystal structure of Ca(2+)-calmodulin bound to this conserved site reveals that calmodulin recognizes two hydrophobic anchor residues at a novel "1-17" spacing that brings the calmodulin lobes close together but prevents them from contacting one another. NMR residual dipolar couplings demonstrate that the detailed structure of each lobe is preserved in solution but also show that the lobes experience domain motions within the complex. FRET measurements confirm the close approach of the lobes in binding the 1-17 target and show that calmodulin binds with one lobe to a peptide lacking the second anchor. We suggest that calmodulin regulates the Ca(2+) channel by switching between the contiguous binding mode seen in our crystal structure and a state where one lobe of calmodulin contacts the conserved binding site while the other interacts with a noncontiguous site on the channel.
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The line below this paragraph, {{ABSTRACT_PUBMED_17027503}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17027503 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17027503}}
==About this Structure==
==About this Structure==
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[[Category: Ef-hand]]
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[[Category: Type-2 turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:07:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:42 2008''

Revision as of 08:14, 28 July 2008

Image:2bcx.png

Template:STRUCTURE 2bcx

Crystal structure of calmodulin in complex with a ryanodine receptor peptide

Template:ABSTRACT PUBMED 17027503

About this Structure

2BCX is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode., Maximciuc AA, Putkey JA, Shamoo Y, Mackenzie KR, Structure. 2006 Oct;14(10):1547-56. PMID:17027503

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