This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bdl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bdl.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2bdl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bdl| PDB=2bdl | SCENE= }}
{{STRUCTURE_2bdl| PDB=2bdl | SCENE= }}
-
'''Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor'''
+
===Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor===
-
==Overview==
+
<!--
-
Starting from a potent pantolactone ketoamide cathepsin K inhibitor discovered from structural screening, conversion of the lactone scaffold to a pyrrolidine scaffold allowed exploration of the S(3) subsite of cathepsin K. Manipulation of P3 and P1' groups afforded potent inhibitors with drug-like properties.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16376075}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16376075 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16376075}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Cato]]
[[Category: Cato]]
[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:08:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:30:15 2008''

Revision as of 05:30, 29 July 2008

Template:STRUCTURE 2bdl

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor

Template:ABSTRACT PUBMED 16376075

About this Structure

2BDL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors., Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. Epub 2006 Jan 11. PMID:16376075

Page seeded by OCA on Tue Jul 29 08:30:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools