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2bdl

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{{STRUCTURE_2bdl| PDB=2bdl | SCENE= }}
{{STRUCTURE_2bdl| PDB=2bdl | SCENE= }}
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'''Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor'''
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===Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor===
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==Overview==
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Starting from a potent pantolactone ketoamide cathepsin K inhibitor discovered from structural screening, conversion of the lactone scaffold to a pyrrolidine scaffold allowed exploration of the S(3) subsite of cathepsin K. Manipulation of P3 and P1' groups afforded potent inhibitors with drug-like properties.
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(as it appears on PubMed at http://www.pubmed.gov), where 16376075 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16376075}}
==About this Structure==
==About this Structure==
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[[Category: Cato]]
[[Category: Cato]]
[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:08:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:30:15 2008''

Revision as of 05:30, 29 July 2008

Template:STRUCTURE 2bdl

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor

Template:ABSTRACT PUBMED 16376075

About this Structure

2BDL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors., Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. Epub 2006 Jan 11. PMID:16376075

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