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2bfy

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[[Image:2bfy.gif|left|200px]]
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{{Seed}}
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[[Image:2bfy.png|left|200px]]
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{{STRUCTURE_2bfy| PDB=2bfy | SCENE= }}
{{STRUCTURE_2bfy| PDB=2bfy | SCENE= }}
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'''COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.'''
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===COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.===
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==Overview==
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Aurora family serine/threonine kinases control mitotic progression, and their deregulation is implicated in tumorigenesis. Aurora A and Aurora B, the best-characterized members of mammalian Aurora kinases, are approximately 60% identical but bind to unrelated activating subunits. The structure of the complex of Aurora A with the TPX2 activator has been reported previously. Here, we report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP) activator and with the small molecule inhibitor Hesperadin. The Aurora B:INCENP complex is remarkably different from the Aurora A:TPX2 complex. INCENP forms a crown around the small lobe of Aurora B and induces the active conformation of the T loop allosterically. The structure represents an intermediate state of activation of Aurora B in which the Aurora B C-terminal segment stabilizes an open conformation of the catalytic cleft, and a critical ion pair in the kinase active site is impaired. Phosphorylation of two serines in the carboxyl terminus of INCENP generates the fully active kinase.
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The line below this paragraph, {{ABSTRACT_PUBMED_15866179}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15866179 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15866179}}
==About this Structure==
==About this Structure==
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[[Category: Mitosis]]
[[Category: Mitosis]]
[[Category: Transferase complex]]
[[Category: Transferase complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:14:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:46:35 2008''

Revision as of 01:46, 29 July 2008

Image:2bfy.png

Template:STRUCTURE 2bfy

COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.

Template:ABSTRACT PUBMED 15866179

About this Structure

2BFY is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin., Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A, Mol Cell. 2005 Apr 29;18(3):379-91. PMID:15866179

Page seeded by OCA on Tue Jul 29 04:46:35 2008

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