We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2bhr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bhr.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2bhr.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bhr| PDB=2bhr | SCENE= }}
{{STRUCTURE_2bhr| PDB=2bhr | SCENE= }}
-
'''DENGUE VIRUS RNA HELICASE'''
+
===DENGUE VIRUS RNA HELICASE===
-
==Overview==
+
<!--
-
Dengue fever is an important emerging public health concern, with several million viral infections occurring annually, for which no effective therapy currently exists. The NS3 protein from Dengue virus is a multifunctional protein of 69 kDa, endowed with protease, helicase, and nucleoside 5'-triphosphatase (NTPase) activities. Thus, NS3 plays an important role in viral replication and represents a very interesting target for the development of specific antiviral inhibitors. We present the structure of an enzymatically active fragment of the Dengue virus NTPase/helicase catalytic domain to 2.4 A resolution. The structure is composed of three domains, displays an asymmetric distribution of charges on its surface, and contains a tunnel large enough to accommodate single-stranded RNA. Its C-terminal domain adopts a new fold compared to the NS3 helicase of hepatitis C virus, which has interesting implications for the evolution of the Flaviviridae replication complex. A bound sulfate ion reveals residues involved in the metal-dependent NTPase catalytic mechanism. Comparison with the NS3 hepatitis C virus helicase complexed to single-stranded DNA would place the 3' single-stranded tail of a nucleic acid duplex in the tunnel that runs across the basic face of the protein. A possible model for the unwinding mechanism is proposed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16051821}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16051821 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16051821}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Nucleoside triphosphatase]]
[[Category: Nucleoside triphosphatase]]
[[Category: Rna helicase]]
[[Category: Rna helicase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:18:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:38:13 2008''

Revision as of 09:38, 27 July 2008

Image:2bhr.png

Template:STRUCTURE 2bhr

DENGUE VIRUS RNA HELICASE

Template:ABSTRACT PUBMED 16051821

About this Structure

2BHR is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A., Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J, J Virol. 2005 Aug;79(16):10278-88. PMID:16051821

Page seeded by OCA on Sun Jul 27 12:38:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bhr"
Personal tools