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2bi6

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[[Image:2bi6.jpg|left|200px]]
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{{STRUCTURE_2bi6| PDB=2bi6 | SCENE= }}
{{STRUCTURE_2bi6| PDB=2bi6 | SCENE= }}
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'''NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM'''
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===NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM===
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==Overview==
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Bromelain inhibitor VI from pineapple stem (BI-VI) is a unique double-chain inhibitor with an 11-residue light chain and a 41-residue heavy chain by disulfide bonds and inhibits the cysteine proteinase bromelain competitively. The structure of BI-VI in aqueous solution was determined using nuclear magnetic resonance spectroscopy and simulated annealing-based calculations. Its three-dimensional structure was shown to be composed of two distinct domains, each of which is formed by a three-stranded antiparallel beta-sheet. Unexpectedly, BI-VI was found to share a similar folding and disulfide bond connectivities not with cystatin superfamily inhibitors which inhibit the same cysteine proteinases but with the Bowman-Birk trypsin/chymotrypsin inhibitor from soybean (BBI-I). BBI-I is a 71-residue inhibitor which has two independent inhibitory sites toward the serine proteinases trypsin and chymotrypsin. These structural similarities with BBI-I suggest that they have evolved from a common ancestor and differentiated in function during a course of molecular evolution.
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{{ABSTRACT_PUBMED_8611527}}
==About this Structure==
==About this Structure==
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2BI6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA].
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2BI6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA].
==Reference==
==Reference==
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[[Category: Hatano, K I.]]
[[Category: Hatano, K I.]]
[[Category: Cysteine protease inhibitor]]
[[Category: Cysteine protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:19:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:55:46 2008''

Revision as of 15:55, 28 July 2008

Image:2bi6.png

Template:STRUCTURE 2bi6

NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM

Template:ABSTRACT PUBMED 8611527

About this Structure

2BI6 is a Protein complex structure of sequences from Ananas comosus. Full experimental information is available from OCA.

Reference

Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean., Hatano K, Kojima M, Tanokura M, Takahashi K, Biochemistry. 1996 Apr 30;35(17):5379-84. PMID:8611527

Page seeded by OCA on Mon Jul 28 18:55:46 2008

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