2biw

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[[Image:2biw.gif|left|200px]]
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[[Image:2biw.png|left|200px]]
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==Overview==
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{{ABSTRACT_15821095}}
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Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed beta-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this carotenoid changed from a straight all-trans to a cranked cis-trans-cis conformation. The remaining trans bond is located at the dioxygen-ligated Fe2+ and cleaved by oxygen.
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==About this Structure==
==About this Structure==
2BIW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. The following page contains interesting information on the relation of 2BIW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb66_1.html Carotenoid Oxygenase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIW OCA].
2BIW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. The following page contains interesting information on the relation of 2BIW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb66_1.html Carotenoid Oxygenase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIW OCA].
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==Reference==
 
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The structure of a retinal-forming carotenoid oxygenase., Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE, Science. 2005 Apr 8;308(5719):267-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15821095 15821095]
 
[[Category: Carotenoid Oxygenase]]
[[Category: Carotenoid Oxygenase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Oxygenase,non-heme iron,carotenoid cleavage,retinal formation]]
[[Category: Oxygenase,non-heme iron,carotenoid cleavage,retinal formation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:21:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:13:12 2008''

Revision as of 15:13, 26 June 2008

Image:2biw.png

Template:STRUCTURE 2biw

CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME


Template:ABSTRACT 15821095

About this Structure

2BIW is a Single protein structure of sequence from Synechocystis sp.. The following page contains interesting information on the relation of 2BIW with [Carotenoid Oxygenase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:13:12 2008

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