2bka

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{{STRUCTURE_2bka| PDB=2bka | SCENE= }}
{{STRUCTURE_2bka| PDB=2bka | SCENE= }}
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'''CC3(TIP30)CRYSTAL STRUCURE'''
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===CC3(TIP30)CRYSTAL STRUCURE===
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==Overview==
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CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic properties. The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent of AF-2 function (CIA) and the c-myc gene. Previous biochemical studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-dependent protein kinase catalytic subunit was proposed. By contrast, bioinformatics studies suggested a relationship of CC3 to the short chain dehydrogenase reductase family. To clarify details of the CC3 structural family and ligand binding properties, we have determined the crystal structure of CC3 at 1.7-A resolution. CC3 has a short chain dehydrogenase reductase fold and binding specificity for NADPH, yet it is unlikely to be normally enzymatically active because it is monomeric. These structural results, in conjunction with data from earlier mutagenesis work on the nucleotide binding motif, suggest that NADPH binding is important for the biological activity of CC3, including interaction with importins and with the CIA/c-myc system. CC3 provides an example of the adaptation of a metabolic enzyme fold to include a regulatory role, as also seen in the case of the NADH-binding co-repressor CtBP.
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(as it appears on PubMed at http://www.pubmed.gov), where 15728189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15728189}}
==About this Structure==
==About this Structure==
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[[Category: Tip30]]
[[Category: Tip30]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:24:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:48:24 2008''

Revision as of 12:48, 27 July 2008

Image:2bka.png

Template:STRUCTURE 2bka

CC3(TIP30)CRYSTAL STRUCURE

Template:ABSTRACT PUBMED 15728189

About this Structure

2BKA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor., El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK, J Biol Chem. 2005 May 6;280(18):18229-36. Epub 2005 Feb 22. PMID:15728189

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