2bks

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{{STRUCTURE_2bks| PDB=2bks | SCENE= }}
{{STRUCTURE_2bks| PDB=2bks | SCENE= }}
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'''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''
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===CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX===
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==Overview==
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We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
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(as it appears on PubMed at http://www.pubmed.gov), where 15837327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837327}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:05:20 2008''

Revision as of 21:05, 27 July 2008

Image:2bks.png

Template:STRUCTURE 2bks

CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX

Template:ABSTRACT PUBMED 15837327

About this Structure

2BKS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327

Page seeded by OCA on Mon Jul 28 00:05:20 2008

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