2bkz

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[[Image:2bkz.gif|left|200px]]
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{{Seed}}
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[[Image:2bkz.png|left|200px]]
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{{STRUCTURE_2bkz| PDB=2bkz | SCENE= }}
{{STRUCTURE_2bkz| PDB=2bkz | SCENE= }}
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'''STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611'''
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===STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611===
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==Overview==
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The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.
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The line below this paragraph, {{ABSTRACT_PUBMED_15713378}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15713378 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15713378}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:26:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:13:24 2008''

Revision as of 15:13, 27 July 2008

Image:2bkz.png

Template:STRUCTURE 2bkz

STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611

Template:ABSTRACT PUBMED 15713378

About this Structure

2BKZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzodipyrazoles: a new class of potent CDK2 inhibitors., D'Alessio R, Bargiotti A, Metz S, Brasca MG, Cameron A, Ermoli A, Marsiglio A, Polucci P, Roletto F, Tibolla M, Vazquez ML, Vulpetti A, Pevarello P, Bioorg Med Chem Lett. 2005 Mar 1;15(5):1315-9. PMID:15713378

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