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2bm4

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[[Image:2bm4.gif|left|200px]]
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{{Seed}}
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[[Image:2bm4.png|left|200px]]
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{{STRUCTURE_2bm4| PDB=2bm4 | SCENE= }}
{{STRUCTURE_2bm4| PDB=2bm4 | SCENE= }}
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'''THE STRUCTURE OF MFPA (RV3361C, C2 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.'''
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===THE STRUCTURE OF MFPA (RV3361C, C2 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.===
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==Overview==
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Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_15933203}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15933203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15933203}}
==About this Structure==
==About this Structure==
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[[Category: Pentapeptide repeat proteins,fluroquinolone resistance]]
[[Category: Pentapeptide repeat proteins,fluroquinolone resistance]]
[[Category: Right-handed quadrilateral beta-helix]]
[[Category: Right-handed quadrilateral beta-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:28:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:16:15 2008''

Revision as of 16:16, 27 July 2008

Image:2bm4.png

Template:STRUCTURE 2bm4

THE STRUCTURE OF MFPA (RV3361C, C2 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.

Template:ABSTRACT PUBMED 15933203

About this Structure

2BM4 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA., Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS, Science. 2005 Jun 3;308(5727):1480-3. PMID:15933203

Page seeded by OCA on Sun Jul 27 19:16:15 2008

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