2bmi

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{{STRUCTURE_2bmi| PDB=2bmi | SCENE= }}
{{STRUCTURE_2bmi| PDB=2bmi | SCENE= }}
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'''METALLO-BETA-LACTAMASE'''
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===METALLO-BETA-LACTAMASE===
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==Overview==
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beta-Lactamases are extracellular or periplasmic bacterial enzymes which confer resistance to beta-lactam antibiotics. On the basis of their catalytic mechanisms, they can be divided into two major groups: active-site serine enzymes (classes A, C and D) and the ZnII enzymes (class B). The first crystal structure of a class B enzyme, the metallo-beta-lactamase from Bacillus cereus, has been solved at 2.5 A resolution [Carfi, Pares, Duee, Galleni, Duez, Frere &amp; Dideberg (1995). EMBO J. 14, 4914-4921]. Recently, the crystal structure of the metallo-beta-lactamase from Bacteroides fragilis has been determined in a tetragonal space group [Concha, Rasmussen, Bush &amp; Herzberg (1996). Structure, 4, 823-836]. The structure of the metallo-beta-lactamase from B. fragilis in an orthorhombic crystal form at 2.0 A resolution is reported here. The final crystallographic R is 0.196 for all the 32501 observed reflections in the range 10-2.0 A. The refined model includes 458 residues, 437 water molecules, four zinc and two sodium ions. These structures are discussed with reference to Zn binding and activity. A catalytic mechanism is proposed which is coherent with metallo-beta-lactamases being active with either one Zn ion (as in Aeromonas hydrophila) or two Zn ions (as in B. fragilis) bound to the protein.
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{{ABSTRACT_PUBMED_9761816}}
==About this Structure==
==About this Structure==
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[[Category: Metallo beta-lactamase]]
[[Category: Metallo beta-lactamase]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:47:16 2008''

Revision as of 09:47, 29 July 2008

Image:2bmi.png

Template:STRUCTURE 2bmi

METALLO-BETA-LACTAMASE

Template:ABSTRACT PUBMED 9761816

About this Structure

2BMI is a Single protein structure of sequence from Bacteroides fragilis. This structure supersedes the now removed PDB entry 1bmi. Full crystallographic information is available from OCA.

Reference

X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form., Carfi A, Duee E, Paul-Soto R, Galleni M, Frere JM, Dideberg O, Acta Crystallogr D Biol Crystallogr. 1998 Jan 1;54(Pt 1):45-57. PMID:9761816

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