2bn8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bn8.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2bn8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bn8| PDB=2bn8 | SCENE= }}
{{STRUCTURE_2bn8| PDB=2bn8 | SCENE= }}
-
'''SOLUTION STRUCTURE AND INTERACTIONS OF THE E.COLI CELL DIVISION ACTIVATOR PROTEIN CEDA'''
+
===SOLUTION STRUCTURE AND INTERACTIONS OF THE E.COLI CELL DIVISION ACTIVATOR PROTEIN CEDA===
-
==Overview==
+
<!--
-
CedA is a protein that is postulated to be involved in the regulation of cell division in Escherichia coli and related organisms; however, little biological data about its possible mode of action are available. Here we present a three-dimensional structure of this protein as determined by NMR spectroscopy. The protein is made up of four antiparallel beta-strands, an alpha-helix, and a large unstructured stretch of residues at the N-terminus. It shows structural similarity to a family of DNA-binding proteins which interact with dsDNA via a three-stranded beta-sheet, suggesting that CedA may be a DNA-binding protein. The putative binding surface of CedA is predominantly positively charged with a number of basic residues surrounding a groove largely dominated by aromatic residues. NMR chemical shift perturbations and gel-shift experiments performed with CedA confirm that the protein binds dsDNA, and its interaction is mediated primarily via the beta-sheet.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15865419}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15865419 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15865419}}
==About this Structure==
==About this Structure==
-
2BN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA].
+
2BN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Cell cycle protein]]
[[Category: Cell cycle protein]]
[[Category: Cell division activator protein]]
[[Category: Cell division activator protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:31:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:46:01 2008''

Revision as of 12:46, 29 July 2008

Image:2bn8.png

Template:STRUCTURE 2bn8

SOLUTION STRUCTURE AND INTERACTIONS OF THE E.COLI CELL DIVISION ACTIVATOR PROTEIN CEDA

Template:ABSTRACT PUBMED 15865419

About this Structure

2BN8 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure and interactions of the Escherichia coli cell division activator protein CedA., Chen HA, Simpson P, Huyton T, Roper D, Matthews S, Biochemistry. 2005 May 10;44(18):6738-44. PMID:15865419

Page seeded by OCA on Tue Jul 29 15:46:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bn8"
Personal tools