2bpy

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{{STRUCTURE_2bpy| PDB=2bpy | SCENE= }}
{{STRUCTURE_2bpy| PDB=2bpy | SCENE= }}
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'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''
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===HIV-1 PROTEASE-INHIBITOR COMPLEX===
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==Overview==
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The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.
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(as it appears on PubMed at http://www.pubmed.gov), where 9757136 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9757136}}
==About this Structure==
==About this Structure==
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[[Category: Acid protease]]
[[Category: Acid protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:37:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:13:27 2008''

Revision as of 06:13, 28 July 2008

Image:2bpy.png

Template:STRUCTURE 2bpy

HIV-1 PROTEASE-INHIBITOR COMPLEX

Template:ABSTRACT PUBMED 9757136

About this Structure

2BPY is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:9757136

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