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2bub

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{{STRUCTURE_2bub| PDB=2bub | SCENE= }}
{{STRUCTURE_2bub| PDB=2bub | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR'''
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===CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR===
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==Overview==
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The co-crystal structure of beta-phenethylamine fragment inhibitor 5 bound to DPP-IV revealed that the phenyl ring occupied the proline pocket of the enzyme. This finding provided the basis for a general hypothesis of a reverse binding mode for beta-phenethylamine-based DPP-IV inhibitors. Novel inhibitor design concepts that obviate substrate-like structure-activity relationships (SAR) were thereby enabled, and novel, potent inhibitors were discovered.
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(as it appears on PubMed at http://www.pubmed.gov), where 16376544 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16376544}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:11:42 2008''

Revision as of 03:11, 28 July 2008

Image:2bub.png

Template:STRUCTURE 2bub

CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR

Template:ABSTRACT PUBMED 16376544

About this Structure

2BUB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors., Nordhoff S, Cerezo-Galvez S, Feurer A, Hill O, Matassa VG, Metz G, Rummey C, Thiemann M, Edwards PJ, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1744-8. Epub 2006 Jan 11. PMID:16376544

Page seeded by OCA on Mon Jul 28 06:11:42 2008

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