2bud

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[[Image:2bud.gif|left|200px]]
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{{Seed}}
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[[Image:2bud.png|left|200px]]
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{{STRUCTURE_2bud| PDB=2bud | SCENE= }}
{{STRUCTURE_2bud| PDB=2bud | SCENE= }}
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'''THE SOLUTION STRUCTURE OF THE CHROMO BARREL DOMAIN FROM THE MALES-ABSENT ON THE FIRST (MOF) PROTEIN'''
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===THE SOLUTION STRUCTURE OF THE CHROMO BARREL DOMAIN FROM THE MALES-ABSENT ON THE FIRST (MOF) PROTEIN===
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==Overview==
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We report here the structure of the putative chromo domain from MOF, a member of the MYST family of histone acetyltransferases that acetylates histone H4 at Lys-16 and is part of the dosage compensation complex in Drosophila. We found that the structure of this domain is a beta-barrel that is distinct from the alpha + beta fold of the canonical chromo domain. Despite the differences, there are similarities that support an evolutionary relationship between the two domains, and we propose the name "chromo barrel." The chromo barrel domains may be divided into two groups, MSL3-like and MOF-like, on the basis of whether a group of conserved aromatic residues is present or not. The structure suggests that, although the MOF-like domains may have a role in RNA binding, the MSL3-like domains could instead bind methylated residues. The MOF chromo barrel shares a common fold with other chromatin-associated modules, including the MBT-like repeat, Tudor, and PWWP domains. This structural similarity suggests a probable evolutionary pathway from these other modules to the canonical chromo domains (or vice versa) with the chromo barrel domain representing an intermediate structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 15964847 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15964847}}
==About this Structure==
==About this Structure==
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2BUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUD OCA].
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2BUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUD OCA].
==Reference==
==Reference==
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[[Category: Mof,hat,acetyl-transfer,dosage compensation complex,dcc]]
[[Category: Mof,hat,acetyl-transfer,dosage compensation complex,dcc]]
[[Category: Royal family,chromodomain like,beta barrel,transferase acyltransferase]]
[[Category: Royal family,chromodomain like,beta barrel,transferase acyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:48:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:56:51 2008''

Revision as of 13:56, 28 July 2008

Image:2bud.png

Template:STRUCTURE 2bud

THE SOLUTION STRUCTURE OF THE CHROMO BARREL DOMAIN FROM THE MALES-ABSENT ON THE FIRST (MOF) PROTEIN

Template:ABSTRACT PUBMED 15964847

About this Structure

2BUD is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Structure of the chromo barrel domain from the MOF acetyltransferase., Nielsen PR, Nietlispach D, Buscaino A, Warner RJ, Akhtar A, Murzin AG, Murzina NV, Laue ED, J Biol Chem. 2005 Sep 16;280(37):32326-31. Epub 2005 Jun 17. PMID:15964847

Page seeded by OCA on Mon Jul 28 16:56:51 2008

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